Organic letters

One-Pot, Two-Step Conversion of Aldehydes to Phosphonyl-and Sulfonylpyrazoles Using Bestmann–Ohira Reagent

R Kumar, D Verma, SM Mobin, INN Namboothiri

文献索引：Kumar, Rahul; Verma, Deepti; Mobin, Shaikh M.; Namboothiri, Irishi N. N. Organic Letters, 2012 , vol. 14, # 16 p. 4070 - 4073

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被引用次数: 24

摘要

A one-pot, two-step, three-component method for the conversion of commercially available aldehydes to phosphonylpyrazoles has been developed, demonstrating, for the first time, the dual reactivity of the Bestmann–Ohira reagent (BOR) in a single-pot transformation. This method, extended to the synthesis of sulfonylpyrazoles by employing BOR in the first step and a diazomethyl sulfone in the second step, is complementary, with regard to ...