N-Substituted pyrroles were synthesized under neat conditions by the reaction of aromatic amines with 2, 5-dimethoxytetrahydrofuran in excellent yields. ... N-Substituted pyrroles were synthesized under neat conditions by the reaction of aromatic amines with 2, 5-dimethoxytetrahydrofuran in excellent yields. ... Pyrroles play a pivotal role in the context of heterocyclic chemistry, medicinal chemistry, and synthetic organic chemistry. [ 1 1. Hayakawa , Y. ; Kawasaki , K. ; Seto , H. ...