Tetrahedron letters

Practical copper-catalyzed N-arylation of nitrogen heterocycles with aryl halides under ligand and additive free conditions

JWW Chang, X Xu, PWH Chan

文献索引：Chang, Joyce Wei Wei; Xu, Xiuhui; Chan, Philip Wai Hong Tetrahedron Letters, 2007 , vol. 48, # 2 p. 245 - 248

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被引用次数: 68

摘要

N-arylation of a wide variety of nitrogen heterocycles with aryl iodides catalyzed by copper iodide under mild ligand and additive free conditions (nBu4NBr, PhMe, NaOH, reflux, 22h) was accomplished in good to excellent yields (up to 95%) and substrate conversions (up to 99%).