Tetrahedron Letters

New strategy for the synthesis of N-aryl pyrroles: Cu-catalyzed C–N cross-coupling reaction of trans-4-hydroxy-l-proline with aryl halides

VP Reddy, AV Kumar, KR Rao

文献索引：Reddy, V. Prakash; Kumar, A. Vijay; Rao, K. Rama Tetrahedron Letters, 2011 , vol. 52, # 7 p. 777 - 780

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被引用次数: 29

摘要

trans-4-Hydroxy-l-proline is used for the first time as an effective nucleophilic coupling partner with aryl halides mediated by copper iodide with Cs2CO3 as the base and DMSO as the solvent. Utilizing this protocol cross-coupling of trans-4-hydroxy-l-proline with a wide variety of substituted aryl halides to produce N-aryl pyrroles in moderate to good yields.