Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: Unique structural analogs of tacrine based on the BCD …

…, CA Zificsak, A Neeno-Eckwall, RP Hsung

文献索引：Degen, Shane J.; Mueller, Kristen L.; Shen, Hong C.; Mulder, Jason A.; Golding, Geoffrey M.; Wei, Lin-li; Zificsak, Craig A.; Neeno-Eckwall, Amy; Hsung, Richard P. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 973 - 978

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被引用次数: 22

摘要

A general approach to synthesis of dihydroxanthone derivatives is described here. In vitro evaluation of these dihydroxanthones demonstrated that some derivatives possess moderate anti-cholinesterase activities and better selectivities than tacrine for acetylcholinesterase over butyrylcholinesterase. Structural effects on anti-cholinesterase activities were also examined, and docking experiments were carried out to provide ...