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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Design and effective synthesis of novel templates, 3, 7-diphenyl-4-amino-thieno and furo-[3, 2-c] pyridines as protein kinase inhibitors and in vitro evaluation targeting …

…, EN Nartey, KE Hightower, L Kane-Carson

文献索引：Miyazaki, Yasushi; Nakano, Masato; Sato, Hideyuki; Truesdale, Anne T.; Stuart, J. Darren; Nartey, Eldridge N.; Hightower, Kendra E.; Kane-Carson, Laurie Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 250 - 254

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被引用次数: 44

摘要

A novel class of 3, 7-diphenyl-4-amino-thieno and furo [3, 2-c] pyridine has been designed based on pharmacophore models of ATP competitive kinase inhibitors. Versatile synthetic methods via double Suzuki coupling to explore SAR have been established and potent inhibitors against angiogenetic targets, VEGFR2, Tie-2, and EphB4, have been successfully discovered.

2-呋喃丙烯酸结构式

2-呋喃丙烯酸

~65%

3-(furan-2-yl)prop-2-enoyl azide结构式

3-(furan-2-yl)p...

糠醛结构式

~%

3-溴呋喃并[3,2-c]吡啶-4-胺结构式

3-溴呋喃并[3,2-c]吡啶-4-胺

3-(furan-2-yl)prop-2-enoyl azide结构式

3-(furan-2-yl)p...

~%

3-溴呋喃并[3,2-c]吡啶-4-胺结构式

3-溴呋喃并[3,2-c]吡啶-4-胺

4,5-二氢-4-氧代呋喃[3,2]吡啶结构式

4,5-二氢-4-氧代呋喃[3,2]吡啶

~%

3-溴呋喃并[3,2-c]吡啶-4-胺结构式

3-溴呋喃并[3,2-c]吡啶-4-胺

2-呋喃丙烯酸结构式

2-呋喃丙烯酸

~%

3-溴呋喃并[3,2-c]吡啶-4-胺结构式

3-溴呋喃并[3,2-c]吡啶-4-胺

2-(2'--Furyl)-1-isocyanato-ethylen结构式

2-(2'--Furyl)-1...

~%

3-溴呋喃并[3,2-c]吡啶-4-胺结构式

3-溴呋喃并[3,2-c]吡啶-4-胺

4-氯呋喃并[3,2-c]吡啶结构式

4-氯呋喃并[3,2-c]吡啶

~%

3-溴呋喃并[3,2-c]吡啶-4-胺结构式

3-溴呋喃并[3,2-c]吡啶-4-胺

2-呋喃丙烯酸结构式

2-呋喃丙烯酸

~%

4,5-二氢-4-氧代呋喃[3,2]吡啶结构式

4,5-二氢-4-氧代呋喃[3,2]吡啶

2-(2'--Furyl)-1-isocyanato-ethylen结构式

2-(2'--Furyl)-1...

~%

4,5-二氢-4-氧代呋喃[3,2]吡啶结构式

4,5-二氢-4-氧代呋喃[3,2]吡啶

3-(furan-2-yl)prop-2-enoyl azide结构式

3-(furan-2-yl)p...

~%

4,5-二氢-4-氧代呋喃[3,2]吡啶结构式

4,5-二氢-4-氧代呋喃[3,2]吡啶

糠醛结构式

~%

4,5-二氢-4-氧代呋喃[3,2]吡啶结构式

4,5-二氢-4-氧代呋喃[3,2]吡啶

3-溴-4-羟基噻吩并吡啶结构式

3-溴-4-羟基噻吩并吡啶

~99%

3-溴-4-氯噻吩并[3,2-c]吡啶结构式

3-溴-4-氯噻吩并[3,2-c]吡啶

trans-3-(4-bromothiophen-2-yl)-acryloyl azide结构式

trans-3-(4-brom...

~%

3-溴-4-氯噻吩并[3,2-c]吡啶结构式

3-溴-4-氯噻吩并[3,2-c]吡啶

4-溴-2-噻吩甲醛结构式

4-溴-2-噻吩甲醛

~%

3-溴-4-氯噻吩并[3,2-c]吡啶结构式

3-溴-4-氯噻吩并[3,2-c]吡啶

3-(4-Bromo-2-thienyl)acrylic acid结构式

3-(4-Bromo-2-th...

~%

3-溴-4-氯噻吩并[3,2-c]吡啶结构式

3-溴-4-氯噻吩并[3,2-c]吡啶

3-bromo-4-chloro-7-iodothieno[3,2-c]pyridine结构式

3-bromo-4-chlor...

~51%

3-溴-7-碘-噻吩并[3,2-c]吡啶-4-胺结构式

3-溴-7-碘-噻吩并[3,2...

trans-3-(4-bromothiophen-2-yl)-acryloyl azide结构式

trans-3-(4-brom...

~%

3-溴-7-碘-噻吩并[3,2-c]吡啶-4-胺结构式

3-溴-7-碘-噻吩并[3,2...

3-bromo-7-iodothieno[3,2-c]pyridin-4(5H)-one结构式

3-bromo-7-iodot...

~%

3-溴-7-碘-噻吩并[3,2-c]吡啶-4-胺结构式

3-溴-7-碘-噻吩并[3,2...

4-溴-2-噻吩甲醛结构式

4-溴-2-噻吩甲醛

~%

3-溴-7-碘-噻吩并[3,2-c]吡啶-4-胺结构式

3-溴-7-碘-噻吩并[3,2...

3-(4-Bromo-2-thienyl)acrylic acid结构式

3-(4-Bromo-2-th...

~%

3-溴-7-碘-噻吩并[3,2-c]吡啶-4-胺结构式

3-溴-7-碘-噻吩并[3,2...

3-溴-7-碘-噻吩并[3,2-c]吡啶-4-胺结构式

3-溴-7-碘-噻吩并[3,2...

3,4,5-三甲氧基苯硼酸结构式

3,4,5-三甲氧基苯硼酸

~53%

3-bromo-7-(3,4,5-trimethoxyphenyl)thieno[3,2-c]pyridin-4-amine结构式

3-bromo-7-(3,4,...

3-溴-4-羟基噻吩并吡啶结构式

3-溴-4-羟基噻吩并吡啶

~%

3-bromo-7-(3,4,5-trimethoxyphenyl)thieno[3,2-c]pyridin-4-amine结构式

3-bromo-7-(3,4,...

trans-3-(4-bromothiophen-2-yl)-acryloyl azide结构式

trans-3-(4-brom...

~%

3-bromo-7-(3,4,5-trimethoxyphenyl)thieno[3,2-c]pyridin-4-amine结构式

3-bromo-7-(3,4,...

3-bromo-7-iodothieno[3,2-c]pyridin-4(5H)-one结构式

3-bromo-7-iodot...

~%

3-bromo-7-(3,4,5-trimethoxyphenyl)thieno[3,2-c]pyridin-4-amine结构式

3-bromo-7-(3,4,...

3-bromo-4-chloro-7-iodothieno[3,2-c]pyridine结构式

3-bromo-4-chlor...

~%

3-bromo-7-(3,4,5-trimethoxyphenyl)thieno[3,2-c]pyridin-4-amine结构式

3-bromo-7-(3,4,...

4-溴-2-噻吩甲醛结构式

4-溴-2-噻吩甲醛

~%

3-bromo-7-(3,4,5-trimethoxyphenyl)thieno[3,2-c]pyridin-4-amine结构式

3-bromo-7-(3,4,...

3-(4-Bromo-2-thienyl)acrylic acid结构式

3-(4-Bromo-2-th...

~%

3-bromo-7-(3,4,5-trimethoxyphenyl)thieno[3,2-c]pyridin-4-amine结构式

3-bromo-7-(3,4,...

The thieno [3, 2-c] pyridine and furo [3, 2-c] pyridine ring...

[New, James S.; Christopher, William L.; Yevich, Joseph P.; Butler, Rhett; Schlemmer, R. Francis; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1147 - 1156]

The thieno [3, 2-c] pyridine and furo [3, 2-c] pyridine ring...

[New, James S.; Christopher, William L.; Yevich, Joseph P.; Butler, Rhett; Schlemmer, R. Francis; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1147 - 1156]