The thieno [3, 2-c] pyridine and furo [3, 2-c] pyridine rings: new pharmacophores with potential antipsychotic activity

…, WL Christopher, JP Yevich, R Butler…

文献索引：New, James S.; Christopher, William L.; Yevich, Joseph P.; Butler, Rhett; Schlemmer, R. Francis; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1147 - 1156

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被引用次数: 77

摘要

Two new arylpiperazine derivatives, the 4-(l-piperazinyl) thieno-and-furo [3, 2-c] pyridine ring systems, have been synthesized and appended via tetramethylene chains to various imide rings. Target compounds from each series were found to have significant activity in the blockade of apomorphine stereotypy and apomorphine-induced climbing, the Sidman avoidance response, and the conditioned avoidance response. In addition, while potent ...