8-Substituted purine derivatives: a new class of lipid-lowering agents

…, M Bani, D Favara, M Gobetti, M Lombroso…

文献索引：Vanotti, E.; Bani, M.; Favara, D.; Gobetti, M.; Lombroso, M.; et al. European Journal of Medicinal Chemistry, 1994 , vol. 29, # 4 p. 287 - 294

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被引用次数: 4

摘要

Abstract A series of purine derivatives have been prepared and their in vivo abilities to lower plasma total cholesterol and triglyceride levels, and to elevate high density lipoprotein (HDL) cholesterol levels in hyperlipemic rats have been tested. Some compounds, among which 8- {2-(R)-hydroxy-3-[(p-isobutoxycarbonyl) phenoxy] propylthio} adenosine 31, 8-{3-[(p- isobutoxycarbonyl) phenoxy]-2-oxopropylthio} adenosine 33 and 8-{3-[(p- ...