8-Substituted purine derivatives: a new class of lipid-lowering agents

…, M Bani, D Favara, M Gobetti, M Lombroso…

Index: Vanotti, E.; Bani, M.; Favara, D.; Gobetti, M.; Lombroso, M.; et al. European Journal of Medicinal Chemistry, 1994 , vol. 29, # 4 p. 287 - 294

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Citation Number: 4

Abstract

Abstract A series of purine derivatives have been prepared and their in vivo abilities to lower plasma total cholesterol and triglyceride levels, and to elevate high density lipoprotein (HDL) cholesterol levels in hyperlipemic rats have been tested. Some compounds, among which 8- {2-(R)-hydroxy-3-[(p-isobutoxycarbonyl) phenoxy] propylthio} adenosine 31, 8-{3-[(p- isobutoxycarbonyl) phenoxy]-2-oxopropylthio} adenosine 33 and 8-{3-[(p- ...