Chemical biology & drug design

Design, Synthesis, and Sustained??Release Property of 1, 3??Cyclic Propanyl Phosphate Ester of 18β??Glycyrrhetinic Acid

W Sun, W Peng, G Li, T Jiang

文献索引：Sun, Weizhi; Peng, Weibing; Li, Guoqiang; Jiang, Tao Chemical Biology and Drug Design, 2011 , vol. 77, # 3 p. 206 - 211

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被引用次数: 6

摘要

A new class of potential prodrugs, 1,3-cyclic propanyl phosphate esters of 18β-glycyrrhetic acid, was designed and synthesized through the key reaction of 18β-glycyrrhetic acid with 1,3-cyclic propanyl phosphate ester catalysed by lithium diisopropylamide. The sustained-release properties of 1,3-cyclic propanyl phosphate esters of 18β-glycyrrhetic acid in vivo were also investigated. The animal experiments showed that 18β-glycyrrhetic acid was released ...