A new class of potential prodrugs, 1,3-cyclic propanyl phosphate esters of 18β-glycyrrhetic acid, was designed and synthesized through the key reaction of 18β-glycyrrhetic acid with 1,3-cyclic propanyl phosphate ester catalysed by lithium diisopropylamide. The sustained-release properties of 1,3-cyclic propanyl phosphate esters of 18β-glycyrrhetic acid in vivo were also investigated. The animal experiments showed that 18β-glycyrrhetic acid was released ...
[Reddy, K. Raja; Colby, Timothy J.; Fujitaki, James M.; Van Poelje, Paul D.; Erion, Mark D. Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 375 - 381]
