Synthesis, analysis, in vitro characterization, and in vivo disposition of a lamivudine–dextran conjugate for selective antiviral delivery to the liver

…, HK Agarwal, A Kumar, K Parang…

文献索引：Reddy, K. Raja; Colby, Timothy J.; Fujitaki, James M.; Van Poelje, Paul D.; Erion, Mark D. Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 375 - 381

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被引用次数: 28

摘要

... HR-MS (ESI-TOF) (m/z): C 35 H 43 N 3 O 5 SSi calcd, 645.2693; found 686.4634 [M + K + 2H] + , 1289.3676 [2M – 1] + . 3 (–)-4-N-(4,4′-Dimethoxytrityl)-2′,3′-dideoxy-3′-thiacytidine (4 ... 1 H NMR (CD 3 OD, δ ppm): 8.53 (d, J = 7.8 Hz, 1H, H-6), 7.32–7.34 (m, 2H, aromatic ...