Journal of the American Chemical Society

Catalytic, enantioselective aldol additions to ketones

SE Denmark, Y Fan

文献索引：Denmark, Scott E.; Fan, Yu Journal of the American Chemical Society, 2002 , vol. 124, # 16 p. 4233 - 4235

全文：HTML全文

被引用次数: 189

摘要

Catalytic, enantioselective additions of a trichlorosilyl ketene acetal to ketones have been demonstrated. The trichlorosilyl enolate of methyl acetate undergoes a rapid and high- yielding aldol addition to a wide range of ketones (aromatic, olefinic, acetylenic, aliphatic) in the presence of a catalytic amount of pyridine N-oxide. Moreover, in the presence of a catalytic amount (10 mol%) of a chiral bispyridine bis N-oxide (possessing both axial and ...