Catalytic, enantioselective additions of a trichlorosilyl ketene acetal to ketones have been demonstrated. The trichlorosilyl enolate of methyl acetate undergoes a rapid and high- yielding aldol addition to a wide range of ketones (aromatic, olefinic, acetylenic, aliphatic) in the presence of a catalytic amount of pyridine N-oxide. Moreover, in the presence of a catalytic amount (10 mol%) of a chiral bispyridine bis N-oxide (possessing both axial and ...
![trichloro[(1-methoxyethenyl)oxy]silane Structure](https://image.chemsrc.com/caspic/472/4519-10-2.png)
