Tetrahedron: Asymmetry

Microbial asymmetric reduction of α-hydroxyketones in the anti-Prelog selectivity

T Tsujigami, T Sugai, H Ohta

文献索引：Tsujigami, Toshikuni; Sugai, Takeshi; Ohta, Hiromichi Tetrahedron Asymmetry, 2001 , vol. 12, # 18 p. 2543 - 2549

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被引用次数: 40

摘要

Yamadazyma farinosa IFO 10896 was found to reduce α-hydroxyketones bearing a phenyl ring to give optically active diols with anti-Prelog selectivity. The distance between the carbonyl group and the phenyl ring was shown to have an interesting effect on the reactivity and selectivity of the enzyme system.