Tetrahedron Letters

Biocatalytic reduction of prochiral aromatic ketones to optically pure alcohols by a coupled enzyme system for cofactor regeneration

Z Yan, Y Nie, Y Xu, X Liu, R Xiao

文献索引：Yan, Zhen; Nie, Yao; Xu, Yan; Liu, Xiang; Xiao, Rong Tetrahedron Letters, 2011 , vol. 52, # 9 p. 999 - 1002

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被引用次数: 11

摘要

A simple, highly efficient, and economical biphasic cell-free system was developed for biocatalytic reduction of prochiral aromatic ketones to furnish enantiopure alcohols. This system is characterized by using endogenous enzymes of the cell-free extract to form enzyme-coupled NADPH recycling system. Besides, it offered much higher productivity than whole cells and greatly simplified the preparation process of biocatalysts in comparison ...