European journal of medicinal chemistry

Synthesis, docking and pharmacological evaluation of novel indole based potential atypical antipsychotics

A Bali, U Sen, T Peshin

文献索引：Bali, Alka; Sen, Umesh; Peshin, Tania European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 477 - 490

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被引用次数: 4

摘要

Abstract A series of substituted indole derivatives have been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypy assays in mice. The compounds 11 and 12 have emerged as important lead compounds showing potential atypical antipsychotic profile. In silico (docking studies) have been carried out to postulate a hypothetical binding model for the target ...