European journal of medicinal chemistry

Synthesis, docking and pharmacological evaluation of novel indole based potential atypical antipsychotics

A Bali, U Sen, T Peshin

Index: Bali, Alka; Sen, Umesh; Peshin, Tania European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 477 - 490

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Citation Number: 4

Abstract

Abstract A series of substituted indole derivatives have been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypy assays in mice. The compounds 11 and 12 have emerged as important lead compounds showing potential atypical antipsychotic profile. In silico (docking studies) have been carried out to postulate a hypothetical binding model for the target ...