Journal of medicinal chemistry

Inactivation of monoamine oxidase B by analogs of the anticonvulsant agent milacemide [2-(n-pentylamino) acetamide]

K Nishimura, X Lu, RB Silverman

文献索引：Nishimura, Kuniko; Lu, Xingliang; Silverman, Richard B. Journal of Medicinal Chemistry, 1993 , vol. 36, # 4 p. 446 - 448

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被引用次数: 9

摘要

Analogues of the anticonvulsant agent milacemide (1, 2-(n-pentylamino) acetamide), in which the carboxamide group is changed to a nitrile (21, a carbethoxy group (3), a carboxylic acid (4), a cyanomethyl group (S), and a trifluoromethyl group (61, were synthesized and tested as substrates and inactivators of monoamine oxidase B (MA0 B). The carboxylic acid was neither a substrate nor an inactivator. The trifluoromethyl ...