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New insights into molecular recognition of 1, 1-bisphosphonic acids by farnesyl diphosphate synthase

M Ferrer-Casal, C Li, M Galizzi, CA Stortz…

文献索引:Ferrer-Casal, Mariana; Li, Catherine; Galizzi, Melina; Stortz, Carlos A.; Szajnman, Sergio H.; Docampo, Roberto; Moreno, Silvia N.J.; Rodriguez, Juan B. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 398 - 405

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被引用次数: 7

摘要

Abstract As part of our project pointed at the search of new antiparasitic agents against American trypanosomiasis (Chagas disease) and toxoplasmosis a series of 2- alkylaminoethyl-1-hydroxy-1, 1-bisphosphonic acids has been designed, synthesized and biologically evaluated against the etiologic agents of these parasitic diseases, Trypanosoma cruzi and Toxoplasma gondii, respectively, and also towards their target enzymes, T. cruzi ...