Microbiological transformations. 33. Fungal epoxide hydrolases applied to the synthesis of enantiopure para-substituted styrene oxides. A mechanistic approach

S Pedragosa-Moreau, C Morisseau…

文献索引：Pedragosa-Moreau; Morisseau; Zylber; Archelas; Baratti; Furstoss Journal of Organic Chemistry, 1996 , vol. 61, # 21 p. 7402 - 7407

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被引用次数: 117

摘要

The biohydrolysis of differently para-substituted styrene oxide derivatives was studied, using whole cells of the fungi Aspergillus niger or Beauveria sulfurescens. These microorganisms proved to be equipped with epoxide hydrolases which are able to achieve these hydrolyses with high enantioselectivity. This allowed the preparation of the optically active epoxides and of the corresponding vicinal diols which were obtained with good to excellent ...