Bioorganic chemistry

A study of the effect on nucleophilic hydrolytic activity of pancreatic elastase, trypsin, chymotrypsin, and leucine aminopeptidase by boronic acids in the presence of …

R Smoum, A Rubinstein, M Srebnik

文献索引：Smoum, Reem; Rubinstein, Abraham; Srebnik, Morris Bioorganic Chemistry, 2003 , vol. 31, # 6 p. 464 - 474

全文：HTML全文

被引用次数: 20

摘要

The hydrolytic activity of trypsin, chymotrypsin, elastase, and leucine aminopeptidase, is inhibited by different boronic acids. However, all the enzymes are inhibited by the compound CbzAla (boro) Gly (OH) 2. Therefore, these additives can control the nucleophilic hydrolytic activity of these enzymes.