Bioorganic & medicinal chemistry letters

Synthesis and evaluation of phenoxy acetic acid derivatives as anti-mycobacterial agents

AA Siddiqui, MA Ali

文献索引：yar, Mohammad Shahar; Siddiqui, Anees Ahmad; Ali, Mohamed Ashraf Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4571 - 4574

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被引用次数: 63

摘要

In present investigation, 2-(4-formyl-2-methoxyphenoxy) acetic acid on condensation with various ketones in methanolic KOH solution yielded the corresponding chalcones (1–3). These corresponding chalcones were reacted with appropriate acid hydrazide in glacial acetic acid led to the formation of phenoxy acetic acid derivatives. All newly synthesized compounds were evaluated for their anti-mycobacterial activities against Mycobacterium ...