Il Farmaco

Synthesis and anti-inflammatory activity of 1-acylthiosemicarbazides, 1, 3, 4-oxadiazoles, 1, 3, 4-thiadiazoles and 1, 2, 4-triazole-3-thiones

E Palaska, G Şahin, P Kelicen, NT Durlu, G Altinok

文献索引：Palaska, Erhan; Sahin, Guelay; Kelicen, Pelin; Durlu; Altinok, Guelcin Farmaco, 2002 , vol. 57, # 2 p. 101 - 107

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被引用次数: 505

摘要

Sixteen 1-(2-naphthyloxyacetyl)-4-substituted-3-thiosemicarbazide, 2-(2-naphthyloxymethyl)- 5-substitutedamino-1, 3, 4-oxadiazole, 2-(2-naphthyloxymethyl)-5-substitutedamino-1, 3, 4- thiadiazole and 5-(2-naphthyloxymethyl)-4-substituted-1, 2, 4-triazole-3-thione derivatives have been prepared and evaluated as orally active anti-inflammatory agents with reduced side-effects. The structures of the compounds were confirmed by IR and 1H NMR spectral ...