Bioorganic & medicinal chemistry letters

Synthesis and evaluation of phenoxy acetic acid derivatives as anti-mycobacterial agents

AA Siddiqui, MA Ali

Index: yar, Mohammad Shahar; Siddiqui, Anees Ahmad; Ali, Mohamed Ashraf Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4571 - 4574

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Citation Number: 63

Abstract

In present investigation, 2-(4-formyl-2-methoxyphenoxy) acetic acid on condensation with various ketones in methanolic KOH solution yielded the corresponding chalcones (1–3). These corresponding chalcones were reacted with appropriate acid hydrazide in glacial acetic acid led to the formation of phenoxy acetic acid derivatives. All newly synthesized compounds were evaluated for their anti-mycobacterial activities against Mycobacterium ...