Novel innovation systems for a cellular approach to continuous process chemistry from discovery to market

T Schwalbe, V Autze, M Hohmann…

文献索引：Schwalbe, Thomas; Autze, Volker; Hohmann, Michael; Stirner, Wolfgang Organic Process Research and Development, 2004 , vol. 8, # 3 p. 440 - 454

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被引用次数: 118

摘要

Continuous processing of liquid/liquid synthesis and microreaction technology are shown to reduce the cost of process development and manufacturing of active pharmaceutical ingredients and other functional molecules on a commercial scale. Combinatorial synthesis systems for continuous chemistry are introduced, and their applications are described. Reactions within these systems scale seamlessly in standardized commercial continuous ...