A series of novel 3-quinolinecarboxylic acid derivatives have been prepared and their antibacterial activity evaluated. These derivatives are characterized by fluorine attached to the 6-position and substituted amino groups appended to the 1-and 7-positions. Structure- activity relationship studies indicate that antibacterial potency is greatest when the 1- substituent is methylamino and the 7-substituent is either 4-methyl-1-piperazinyl, 16, or 1- ...
