Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships

MP Wentland, DM Bailey, JB Cornett…

Index: Wentland; Bailey; Cornett; Dobson; Powles; Wagner Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1103 - 1108

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Citation Number: 59

Abstract

A series of novel 3-quinolinecarboxylic acid derivatives have been prepared and their antibacterial activity evaluated. These derivatives are characterized by fluorine attached to the 6-position and substituted amino groups appended to the 1-and 7-positions. Structure- activity relationship studies indicate that antibacterial potency is greatest when the 1- substituent is methylamino and the 7-substituent is either 4-methyl-1-piperazinyl, 16, or 1- ...

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