Tetrahedron

Regioselective synthesis of pyridines and dihydropyridines derived from β-amino acids and aminophosphonates by reaction of N-vinylic phosphazenes with α, β- …

F Palacios, E Herrán, G Rubiales, C Alonso

文献索引：Palacios, Francisco; Herran, Esther; Rubiales, Gloria; Alonso, Concepcion Tetrahedron, 2007 , vol. 63, # 25 p. 5669 - 5676

全文：HTML全文

被引用次数: 18

摘要

Reaction of N-vinylic phosphazenes with α, β-unsaturated ketones leads to the formation of pyridines derived from β-amino acids in a regioselective fashion. The use of functionalized enones derived from α-acylstyryl-carboxylates or-phosphonates affords biologically active asymmetrical and symmetrical dihydropyridines substituted with carboxylate or phosphonate groups including nitrendipine, felodipine, MRS 1097, and efonidipine analogs.