Tetrahedron

A facile synthesis of (S)-felodipine

K Kwon, JA Shin, HY Lee

文献索引：Kwon, Kuktae; Shin, Jung A.; Lee, Hee-Yoon Tetrahedron, 2011 , vol. 67, # 52 p. 10222 - 10228

全文：HTML全文

被引用次数: 4

摘要

A short and facile synthesis of (S)-felodipine was developed starting from (R)-glycidol as the source of the chiral auxiliary. 2-Hydroxyethyl esters were found to undergo selective transesterification reactions in the presence of other esters. This selective transesterification reaction was applied to the synthesis of (S)-felodipine through selective substitution of the 2- hydroxyethyl group possessing chiral ester with sodium methoxide.