Chemistry letters

DNA Strand Scissions by Hydroxamic Acids-Copper (II) Ion under Aerobic Conditions.

S Hashimoto, R Yamashita, Y Nakamura

文献索引：Hashimoto, Shigeki; Yamashita, Rinichi; Nakamura, Yushin Chemistry Letters, 1992 , # 9 p. 1639 - 1642

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被引用次数: 17

摘要

Carbazolyloxyacetohydroxamic acid (1), 9, 9′-decamethylene-bis- carbazolyloxyacetohydroxamic acid (2), benzohydroxamic acid (3) and acetohydroxamic acid (4) without reducing agent under aerobic conditions induced Col E1 DNA strand scissions with increasing of the activities in the order of 4> 3> 2> 1. Inhibition experiments indicated that hydrogen peroxide and superoxide participated in the reactions, but ...