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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated γ-secretase

…, K Baumann, R Schubenel, C Haass, H Steiner…

文献索引：Narlawar, Rajeshwar; Perez Revuelta, Blanca I.; Baumann, Karlheinz; Schubenel, Robert; Haass, Christian; Steiner, Harald; Schmidt, Boris Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 176 - 182

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被引用次数: 32

摘要

N-Sulfonylated and N-alkylated carbazolyloxyacetic acids were investigated for the inhibition and modulation of the Alzheimer's disease associated γ-secretase. The introduction of a lipophilic substituent, which may vary from arylsulfone to alkyl, turned 2- carbazolyloxyacetic acids into potent γ-secretase modulators. This resulted in the selective reduction of Aβ42 and an increase of the less aggregatory Aβ38 fragment by several ...

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tert-butyl 2-(9-nonylcarbazol-2-yl)oxyacetate结构式

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tert-butyl 2-(9-nonylcarbazol-2-yl)oxyacetate结构式

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tert-butyl 2-(9-decylcarbazol-2-yl)oxyacetate结构式

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tert-butyl 2-(9-decylcarbazol-2-yl)oxyacetate结构式

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tert-butyl 2-(9-decylcarbazol-2-yl)oxyacetate结构式

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2-(9H-carbazol-2-yloxy)acetic acid结构式

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6-methoxy-2-[(4-methoxyphenyl)methoxy]-9H-carbazole结构式

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1-methoxy-7-[(4-methoxyphenyl)methoxy]-9H-carbazole结构式

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1-methoxy-7-[(4-methoxyphenyl)methoxy]-9H-carbazole结构式

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1-methoxy-7-[(4-methoxyphenyl)methoxy]-9H-carbazole结构式

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1-methoxy-7-[(4-methoxyphenyl)methoxy]-9H-carbazole结构式

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8-methoxy-9H-carbazol-2-ol结构式

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