N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated γ-secretase

…, K Baumann, R Schubenel, C Haass, H Steiner…

Index: Narlawar, Rajeshwar; Perez Revuelta, Blanca I.; Baumann, Karlheinz; Schubenel, Robert; Haass, Christian; Steiner, Harald; Schmidt, Boris Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 176 - 182

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Citation Number: 32

Abstract

N-Sulfonylated and N-alkylated carbazolyloxyacetic acids were investigated for the inhibition and modulation of the Alzheimer's disease associated γ-secretase. The introduction of a lipophilic substituent, which may vary from arylsulfone to alkyl, turned 2- carbazolyloxyacetic acids into potent γ-secretase modulators. This resulted in the selective reduction of Aβ42 and an increase of the less aggregatory Aβ38 fragment by several ...

 Related Synthetic Route
N/A Structure

210410-32-5

N/A

~%

tert-butyl 2-(9-octylcarbazol-2-yl)oxyacetate Structure

920982-59-8

tert-butyl 2-(9...

2-Hydroxycarbazole Structure

86-79-3

2-Hydroxycarbazole

~%

tert-butyl 2-(9-octylcarbazol-2-yl)oxyacetate Structure

920982-59-8

tert-butyl 2-(9...

tert-Butyl chloroacetate Structure

107-59-5

tert-Butyl chlo...

~%

tert-butyl 2-(9-octylcarbazol-2-yl)oxyacetate Structure

920982-59-8

tert-butyl 2-(9...

N/A Structure

210410-32-5

N/A

~%

tert-butyl 2-(9-nonylcarbazol-2-yl)oxyacetate Structure

920982-61-2

tert-butyl 2-(9...

2-Hydroxycarbazole Structure

86-79-3

2-Hydroxycarbazole

~%

tert-butyl 2-(9-nonylcarbazol-2-yl)oxyacetate Structure

920982-61-2

tert-butyl 2-(9...

tert-Butyl chloroacetate Structure

107-59-5

tert-Butyl chlo...

~%

tert-butyl 2-(9-nonylcarbazol-2-yl)oxyacetate Structure

920982-61-2

tert-butyl 2-(9...

N/A Structure

210410-32-5

N/A

~%

tert-butyl 2-(9-decylcarbazol-2-yl)oxyacetate Structure

920982-63-4

tert-butyl 2-(9...

2-Hydroxycarbazole Structure

86-79-3

2-Hydroxycarbazole

~%

tert-butyl 2-(9-decylcarbazol-2-yl)oxyacetate Structure

920982-63-4

tert-butyl 2-(9...

tert-Butyl chloroacetate Structure

107-59-5

tert-Butyl chlo...

~%

tert-butyl 2-(9-decylcarbazol-2-yl)oxyacetate Structure

920982-63-4

tert-butyl 2-(9...

4-Boronoanisole Structure

10365-98-7

4-Boronoanisole

1-chloro-4-(4-methoxybenzyloxy)-2-nitrobenzene Structure

236111-74-3

1-chloro-4-(4-m...

~66%

1-(3-methoxyphenyl)-4-[(4-methoxyphenyl)methoxy]-2-nitrobenzene Structure

920982-65-6

1-(3-methoxyphe...

4-Chloro-3-nitrophenol Structure

610-78-6

4-Chloro-3-nitr...

~%

1-(3-methoxyphenyl)-4-[(4-methoxyphenyl)methoxy]-2-nitrobenzene Structure

920982-65-6

1-(3-methoxyphe...

4-Methoxybenzylchloride Structure

824-94-2

4-Methoxybenzyl...

~%

1-(3-methoxyphenyl)-4-[(4-methoxyphenyl)methoxy]-2-nitrobenzene Structure

920982-65-6

1-(3-methoxyphe...

N/A Structure

210410-32-5

N/A

~%

2-(9H-carbazol-2-yloxy)acetic acid Structure

300345-74-8

2-(9H-carbazol-...

4-Chloro-3-nitrophenol Structure

610-78-6

4-Chloro-3-nitr...

~%

6-methoxy-2-[(4-methoxyphenyl)methoxy]-9H-carbazole Structure

920982-66-7

6-methoxy-2-[(4...

4-Methoxybenzylchloride Structure

824-94-2

4-Methoxybenzyl...

~%

6-methoxy-2-[(4-methoxyphenyl)methoxy]-9H-carbazole Structure

920982-66-7

6-methoxy-2-[(4...

1-chloro-4-(4-methoxybenzyloxy)-2-nitrobenzene Structure

236111-74-3

1-chloro-4-(4-m...

~%

6-methoxy-2-[(4-methoxyphenyl)methoxy]-9H-carbazole Structure

920982-66-7

6-methoxy-2-[(4...

1-(3-methoxyphenyl)-4-[(4-methoxyphenyl)methoxy]-2-nitrobenzene Structure

920982-65-6

1-(3-methoxyphe...

~%

1-methoxy-7-[(4-methoxyphenyl)methoxy]-9H-carbazole Structure

920982-67-8

1-methoxy-7-[(4...

6-methoxy-2-[(4-methoxyphenyl)methoxy]-9H-carbazole Structure

920982-66-7

6-methoxy-2-[(4...

4-Chloro-3-nitrophenol Structure

610-78-6

4-Chloro-3-nitr...

~%

1-methoxy-7-[(4-methoxyphenyl)methoxy]-9H-carbazole Structure

920982-67-8

1-methoxy-7-[(4...

4-Methoxybenzylchloride Structure

824-94-2

4-Methoxybenzyl...

~%

1-methoxy-7-[(4-methoxyphenyl)methoxy]-9H-carbazole Structure

920982-67-8

1-methoxy-7-[(4...

1-chloro-4-(4-methoxybenzyloxy)-2-nitrobenzene Structure

236111-74-3

1-chloro-4-(4-m...

~%

1-methoxy-7-[(4-methoxyphenyl)methoxy]-9H-carbazole Structure

920982-67-8

1-methoxy-7-[(4...

1-(3-methoxyphenyl)-4-[(4-methoxyphenyl)methoxy]-2-nitrobenzene Structure

920982-65-6

1-(3-methoxyphe...

~%

1-methoxy-7-[(4-methoxyphenyl)methoxy]-9H-carbazole Structure

920982-67-8

1-methoxy-7-[(4...

6-methoxy-2-[(4-methoxyphenyl)methoxy]-9H-carbazole Structure

920982-66-7

6-methoxy-2-[(4...

1-methoxy-7-[(4-methoxyphenyl)methoxy]-9H-carbazole Structure

920982-67-8

1-methoxy-7-[(4...

~82%

8-methoxy-9H-carbazol-2-ol Structure

920982-71-4

8-methoxy-9H-ca...

1-(3-methoxyphenyl)-4-[(4-methoxyphenyl)methoxy]-2-nitrobenzene Structure

920982-65-6

1-(3-methoxyphe...

~%

8-methoxy-9H-carbazol-2-ol Structure

920982-71-4

8-methoxy-9H-ca...

4-Chloro-3-nitrophenol Structure

610-78-6

4-Chloro-3-nitr...

~%

8-methoxy-9H-carbazol-2-ol Structure

920982-71-4

8-methoxy-9H-ca...

1-chloro-4-(4-methoxybenzyloxy)-2-nitrobenzene Structure

236111-74-3

1-chloro-4-(4-m...

~%

8-methoxy-9H-carbazol-2-ol Structure

920982-71-4

8-methoxy-9H-ca...


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