Tetrahedron letters

Hyaluronan-based glycoclusters as probes for chemical glycobiology

SM Rele, SS Iyer, EL Chaikof

文献索引：Rele, Shyam M.; Iyer, Suri S.; Chaikof, Elliot L. Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5055 - 5060

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被引用次数: 10

摘要

Hyaluronan (HA, 1) is a linear non-sulfated high molecular weight glycosoaminoglycan (GAG) composed of repeating disaccharide units of β-d-glucuronic acid (GlcA) and N-acetyl glucosamine (GlcNAc) linked by alternating β-(1,3) and β-(1,4) glycosidic linkages ( Fig. 1). HA is found in the extracellular matrix, at the cell surface, inside cells, and has been implicated in a variety of biological processes, including inflammation, tumorogenesis, and wound repair. 1 ...