Regio??and Stereoselective Reduction of Diketones and Oxidation of Diols by Biocatalytic Hydrogen Transfer

K Edegger, W Stampfer, B Seisser…

文献索引：Edegger, Klaus; Stampfer, Wolfgang; Seisser, Birgit; Faber, Kurt; Mayer, Sandra F.; Oehrlein, Reinhold; Hafner, Andreas; Kroutil, Wolfgang European Journal of Organic Chemistry, 2006 , # 8 p. 1904 - 1909

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被引用次数: 31

摘要

Abstract The asymmetric reduction of symmetrical and nonsymmetrical diketones as well as the stereoselective oxidation of various diols by biocatalytic hydrogen transfer was investigated by employing lyophilized cells of Rhodococcus ruber DSM 44541 containing alcohol dehydrogense ADH-'A'. Symmetrical and nonsymmetrical diketones at the (ω-1)-and (ω-2)-positions are reduced to the Prelog product with high stereopreference, while ...