Regio??and Stereoselective Reduction of Diketones and Oxidation of Diols by Biocatalytic Hydrogen Transfer

K Edegger, W Stampfer, B Seisser…

Index: Edegger, Klaus; Stampfer, Wolfgang; Seisser, Birgit; Faber, Kurt; Mayer, Sandra F.; Oehrlein, Reinhold; Hafner, Andreas; Kroutil, Wolfgang European Journal of Organic Chemistry, 2006 , # 8 p. 1904 - 1909

Full Text: HTML

Citation Number: 31

Abstract

Abstract The asymmetric reduction of symmetrical and nonsymmetrical diketones as well as the stereoselective oxidation of various diols by biocatalytic hydrogen transfer was investigated by employing lyophilized cells of Rhodococcus ruber DSM 44541 containing alcohol dehydrogense ADH-'A'. Symmetrical and nonsymmetrical diketones at the (ω-1)-and (ω-2)-positions are reduced to the Prelog product with high stereopreference, while ...