The chemistry of alkyl thiosulfate esters. 8.(E, Z)-Ajoene: a potent antithrombotic agent from garlic

E Block, S Ahmad, MK Jain, RW Crecely…

文献索引：Block; Ahmad; Jain; et al. Journal of the American Chemical Society, 1984 , vol. 106, # 26 p. 8295 - 8296

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被引用次数: 235

摘要

Apitz-Castro et al. 4a reported that 2-vinyl-4H-1, 3-dithiin (7) and an unknown compound, now named aj~ ene,~~ are potent antithrombotic agents derived from garlic extract. Unlike several other inhibitors of platelet aggregation, these components have been found to inhibit aggregation induced by all known inductors. 4a We report herein the structural characterization and a simple synthesis of (E, Z)-ajoene (4) as well as 7 from allicin (1). ...