Parallel solid-phase synthesis of diaryltriazoles

M Wrobel, J Aubé, B König

文献索引：Wrobel, Matthias; Aube, Jeffrey; Koenig, Burkhard Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1027 - 1036

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被引用次数: 5

摘要

Abstract A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper (I)-or ruthenium (II)-catalyzed 1, 3- cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide ...