Parallel solid-phase synthesis of diaryltriazoles

M Wrobel, J Aubé, B König

Index: Wrobel, Matthias; Aube, Jeffrey; Koenig, Burkhard Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1027 - 1036

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Citation Number: 5

Abstract

Abstract A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper (I)-or ruthenium (II)-catalyzed 1, 3- cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide ...

~91%

Selective RNA Versus DNA G??Quadruplex Targeting by In Situ ...

[Di Antonio, Marco; Biffi, Giulia; Mariani, Angelica; Raiber, Eun-Ang; Rodriguez, Raphael; Balasubramanian, Shankar Angewandte Chemie - International Edition, 2012 , vol. 51, # 44 p. 11073 - 11078 Angew. Chem., 2012 , vol. 124, # 44 p. 11235 - 11240,5]

Synthesis of a cytotoxic ansamycin hybrid

[Mancuso, Lena; Juerjens, Gerrit; Hermane, Jekaterina; Harmrolfs, Kirsten; Eichner, Simone; Fohrer, Joerg; Collisi, Wera; Sasse, Florenz; Kirschning, Andreas Organic Letters, 2013 , vol. 15, # 17 p. 4442 - 4445]