Tetrahedron letters

Efficient synthesis of 1, 2-seco and 1, 2-seco 2-nor pyrimidine and purine nucleosides

M Azymah, C Chavis, M Lucas, JL Imbach

文献索引：Azymah, Muhammad; Chavis, Claude; Lucas, Marc; Imbach, Jean-Louis Tetrahedron Letters, 1989 , vol. 30, # 45 p. 6165 - 6168

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被引用次数: 18

摘要

Altered nucleosides bearing acyclic variations in the sugar moiety were synthesized either from natural nucleosides 5 (ie 2, 3-seco nucleosides) or by reaction between the appropriate pseudo-sugar moiety and the purine or pyrimidine ring. To date, these latter procedures applied to the synthesis of acyclic nucleosides of the general formula R-0-CH2-B (B= N-9 purinyl or Nl pyrimidinyl) started from halomethyl ethers R-0-CH2X (X= Br, Cl) which were ...