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Synthesis of a purine acyclonucleoside series having pronounced antiviral activity. The glyceropurines

KK Ogilvie, N Nguyen-Ba, MF Gillen…

文献索引:Ogilvie; Nguyen-Ba; Gillen; et al. Canadian Journal of Chemistry, 1984 , vol. 62, # 2 p. 241 - 252

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被引用次数: 66

摘要

The synthesis of a series of purine analogues of the acyclonucleoside compound A*(A-Star, 1) is described. Compounds in this series have been shown to have pronounced activity against herpesviruses. These compounds have been designated" the glycerosides". The glyceropurines are described in this report. Nucleotides have been constructed containing glyceroadenine (A*, compound 1). These nucleotides are resistant to degradation by ...

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