Abstract A number of novel thieno [2, 3-b] pyridines were prepared from the reaction of 1 with unsaturated haloalkanes, and by the reaction of the amino ketones 9 and 10 with DMF dimethylacetal or triethyl orthoformate. The synthesis of novel thieno [2, 3-c] and [3, 2-c] pyridines, and a thieno [2, 3-b; 4, 5-b'] dipyridine are also reported.