Assessment of a potential dopaminergic prodrug moiety in several ring systems

JG Cannon, DC Furlano, RG Dushin…

文献索引：Cannon, Joseph G.; Furlano, David C.; Dushin, Russell G.; Chang, Yu-an; Baird, Stephen R.; et al Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2016 - 2020

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被引用次数: 8

摘要

The ortho hydroxy/methyl, hydroxy/hydroxymethyl, hydroxy/formyl, and hydroxy jcarboxy substitution patterns, some of which confer dopaminergic agonist effects upon 2- aminotetralin ring systems, have been incorporated into 0-phenethylamine, 2-aminoindan, and trans-octahydrobenzo [flquinoline rings. Certain of the 2-aminoindan derivatives displayed pharmacologic properties consistent with their being dopaminergic agonists. ...