Assessment of a potential dopaminergic prodrug moiety in several ring systems

JG Cannon, DC Furlano, RG Dushin…

Index: Cannon, Joseph G.; Furlano, David C.; Dushin, Russell G.; Chang, Yu-an; Baird, Stephen R.; et al Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2016 - 2020

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Citation Number: 8

Abstract

The ortho hydroxy/methyl, hydroxy/hydroxymethyl, hydroxy/formyl, and hydroxy jcarboxy substitution patterns, some of which confer dopaminergic agonist effects upon 2- aminotetralin ring systems, have been incorporated into 0-phenethylamine, 2-aminoindan, and trans-octahydrobenzo [flquinoline rings. Certain of the 2-aminoindan derivatives displayed pharmacologic properties consistent with their being dopaminergic agonists. ...

~71%

Dopamine D3 receptor antagonists. 1. Synthesis and structure...

[Haadsma-Svensson; Cleek; Dinh; Duncan; Haber; Huff; Lajiness; Nichols; Smith; Svensson; Zaya; Carlsson; Lin Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4716 - 4732]

Synthesis and dopaminergic activity of (R)-and (S)-4-hydroxy...

[Cannon, Joseph G.; Dushin, Russell G.; Long, John Paul; Ilhan, Mustafa; Jones, Noel D.; Swartzendruber, John K. Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 515 - 518]