Synthesis and dopaminergic activity of (R)-and (S)-4-hydroxy-2-(di-n-propylamino) indan

…, M Ilhan, ND Jones, JK Swartzendruber

文献索引：Cannon, Joseph G.; Dushin, Russell G.; Long, John Paul; Ilhan, Mustafa; Jones, Noel D.; Swartzendruber, John K. Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 515 - 518

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被引用次数: 27

摘要

Conclusion By use of this approach, the order of potency of each pair of cardiac glycosides can be accounted for by the fact that, kinetically, the effective concentration of those with more restricted rotations is higher although their optimal fitness to the receptor may be similar. The important distinction between the preferred conformation of a biologically active compound in solution before binding to the receptor occurs and the actual conformation ...