Tetrahedron Letters

Synthesis of N-protected α-amino aldehydes from their morpholine amide derivatives

C Douat, A Heitz, J Martinez, JA Fehrentz

文献索引：Douat, Celine; Heitz, Annie; Martinez, Jean; Fehrentz, Jean-Alain Tetrahedron Letters, 2000 , vol. 41, # 1 p. 37 - 40

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被引用次数: 50

摘要

A new method for the synthesis of N-protected α-amino aldehydes was developed. N- Protected α-amino amides of morpholine were easily prepared and then reduced with LiAlH4 to produce clean N-protected α-amino aldehydes. This new scheme of synthesis can be used with Boc, Z and Fmoc amino-protecting groups.