Abstract A facile one step synthesis of a wide variety of N-protected (Boc, Z, Fmoc) α-amino aldehydes under mild conditions is described. Pure N-protected (Boc, Z, Fmoc) α-amino aldehydes were obtained in high yields by reduction of N-protected (Z, Boc, Fmoc)-N- carboxyanhydrides (UNCAs) with equivalent amounts of lithium tris (tertbutoxy) aluminium hydride [LiAlH (Ot-Bu) 3] or lithium tris [(3-ethyl-3-pentyl) oxy] aluminium hydride (LTEPA) ...
[Conroy, Trent; Guo, Jin T.; Linington, Roger G.; Hunt, Nicholas H.; Payne, Richard J. Chemistry - A European Journal, 2011 , vol. 17, # 48 p. 13544 - 13552]