Intermediates in the Catalytic Cycle of Methyl Coenzyme M Reductase: Isotope Exchange is Consistent with Formation of a σ??Alkane–Nickel Complex

S Scheller, M Goenrich, S Mayr…

文献索引：Scheller, Silvan; Goenrich, Meike; Mayr, Stefan; Thauer, Rudolf K.; Jaun, Bernhard Angewandte Chemie - International Edition, 2010 , vol. 49, # 44 p. 8112 - 8115

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被引用次数: 35

摘要

Methyl coenzyme M reductase (MCR) is the key enzyme that catalyzes the last step of methane formation in all methanogenic archaea.[1] It converts the two substrates methyl coenzyme M (CH3-S-CoM) and coenzyme B (CoB-SH) into methane and the corresponding heterodisulfide (CoB-SS-CoM)(Scheme 1).