Tetrahedron letters

L-Proline in an ionic liquid as an efficient and reusable catalyst for direct asymmetric aldol reactions

TP Loh, LC Feng, HY Yang, JY Yang

文献索引：Loh, Teck-Peng; Feng, Li-Chun; Yang, Hai-Yan; Yang, Jian-Ying Tetrahedron Letters, 2002 , vol. 43, # 48 p. 8741 - 8743

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被引用次数: 187

摘要

The asymmetric aldol reaction is one of the most efficient processes for the synthesis of optically active β-hydroxy carbonyl compounds which are important intermediates in organic synthesis. Among them, the direct asymmetric aldol reaction between an aldehyde and an unmodified ketone is the most efficient and attractive from the point of atom-economy. 1. and 2. Recently, the commercially available amino acid l-proline has been elegantly used to catalyze the ...