Synthesis and anti-migrative evaluation of moverastin derivatives

M Sawada, S Kubo, K Matsumura, Y Takemoto…

文献索引：Sawada, Masato; Kubo, Shin-Ichiro; Matsumura, Koji; Takemoto, Yasushi; Kobayashi, Hiroki; Tashiro, Etsu; Kitahara, Takeshi; Watanabe, Hidenori; Imoto, Masaya Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1385 - 1389

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被引用次数: 12

摘要

Cell migration of tumor cells is essential for invasion of the extracellular matrix and for cell dissemination. Inhibition of the cell migration involved in the invasion process represents a potential therapeutic approach to the treatment of tumor metastasis; therefore, a novel series of derivatives of moverastins (moverastins A and B), an inhibitor of tumor cell migration, was designed and chemically synthesized. Among these moverastin derivatives, several ...